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Understanding O-DSMT:

O-DSMT, also known as O-Desmethyltramadol, Omnitram, or simply O-DSMT, stands as an opioid analgesic and serves as the primary active metabolite of tramadol. Its atypical synthetic opioid nature sets it apart from traditional morphinan opiates, presenting a cyclohexane ring bonded to a phenyl ring at R1, with a hydroxy group at R3 and an additional hydroxy group at the same location where the cyclohexane ring is bonded to the phenyl ring (R1). O-DSMT further features a third substitution on its cyclohexane ring at R2, connecting to a dimethylamine group through a methylene bridge.

Pharmacological Insights:

O-DSMT’s pharmacological complexity arises from its racemate of stereoisomers, with both (+) and (−)-O-DSMT exhibiting distinct profiles. While both isomers lack serotonin reuptake inhibitor activity, (−)-O-DSMT retains norepinephrine reuptake inhibitor properties. This unique combination contributes to O-DSMT’s potent μ-opioid agonist characteristics, surpassing tramadol in affinity for δ- and κ-opioid receptors.

Safety and Potency:

The racemate of O-DSMT is more effective than individual enantiomers, reflecting its closely mirrored structure to tramadol. This potency, coupled with the complex pharmacological profile, enhances O-DSMT’s efficacy in managing pain, including neuropathic pain. However, it also underscores the potential for drug interactions and side effects compared to conventional opioids.

Mechanism of Action:

Opioids like O-DSMT exert their effects by binding to and activating μ-opioid receptors, mimicking the structural characteristics of endogenous endorphins. This structural resemblance leads to euphoria, pain relief, and anxiolytic effects, mirroring the natural functions of endorphins released in response to pain, exercise, orgasm, or excitement.

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Other chems: AB-FUBINACA

Additional information


15g, 30g(1oz+), 245g(8oz+), 480g(16oz+)


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